Nature Communications (Mar 2019)
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
- Iria Carballo-Carbajal,
- Ariadna Laguna,
- Jordi Romero-Giménez,
- Thais Cuadros,
- Jordi Bové,
- Marta Martinez-Vicente,
- Annabelle Parent,
- Marta Gonzalez-Sepulveda,
- Núria Peñuelas,
- Albert Torra,
- Beatriz Rodríguez-Galván,
- Andrea Ballabio,
- Takafumi Hasegawa,
- Analía Bortolozzi,
- Ellen Gelpi,
- Miquel Vila
Affiliations
- Iria Carballo-Carbajal
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- Ariadna Laguna
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- Jordi Romero-Giménez
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- Thais Cuadros
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- Jordi Bové
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- Marta Martinez-Vicente
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- Annabelle Parent
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- Marta Gonzalez-Sepulveda
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- Núria Peñuelas
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- Albert Torra
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- Beatriz Rodríguez-Galván
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- Andrea Ballabio
- Telethon Institute of Genetics and Medicine (TIGEM)
- Takafumi Hasegawa
- Department of Neurology, Tohoku University School of Medicine
- Analía Bortolozzi
- Department of Neurochemistry and Neuropharmacology, IIBB–CSIC, August Pi i Sunyer Biomedical Research Institute (IDIBAPS)-Center for Networked Biomedical Research on Mental Health (CIBERSAM)
- Ellen Gelpi
- Neurological Tissue Bank, Biobanc Hospital Clínic-IDIBAPS
- Miquel Vila
- Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
- DOI
- https://doi.org/10.1038/s41467-019-08858-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 19
Abstract
It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent production of human-like neuromelanin within nigral dopaminergic neurons and is associated with a Parkinson’s disease phenotype when allowed to accumulate above a specific threshold.
