Optimization of the composition of solid dispersion of quercetin

Abstract

Increasing the solubility of drugs is one of the most important problems in pharmacy, because most manufactured pharmaceutical substances are sparingly soluble. Typically, such compounds represent Classes II and IV in the biopharmaceutical classification system, which is based on the classification of pharmaceutical substances by solubility and permeability. For poorly soluble substances, the limiting step of the absorption process is usually the degree and dissolution rate, so in the pharmaceutical development, much attention is paid to their improvement. To solve this problem, the technology of solid dispersions creation is used. The aim of the work was to optimize the composition of quercetin solid dispersion, whose therapeutic use is limited due to its degree of solubility in an aqueous medium.

Keywords

• polyethyleneoxide-6000
• β-cyclodextrin
• polyvinylpyrrolidone
• mathematical planning method
• quercetin
• solid dispersions