Synthesis and evaluation of anti-inflammatory, antioxidant and antimicrobial activities of densely functionalized novel benzo [d] imidazolyl tetrahydropyridine carboxylates

Abstract

A series of novel benzo[d]imidazolyl tetrahydropyridine carboxylates 7a–n have been synthesized by one-pot multi-component reaction of (E)-5-(benzylidene amino)-1H-benzo[d]imidazole-2-thiol 3, 5-amino-2-mercapto-benzimidazole 4, aromatic aldehyde 5, and ethyl acetoacetate 6 in acetonitrile using ceric ammonium nitrate (CAN) as Lewis acid catalyst, and evaluated for their anti-inflammatory, antioxidant, antibacterial and antifungal activities. All tested compounds showed appreciable activity against the standard drugs.

Keywords

• 2-Mercapto-5-aminobenzimidazole
• Benzo[d]imidazolyl tetrahydropyridine carboxylates
• Ceric ammonium nitrate
• Anti-inflammatory
• Antioxidant
• Antimicrobial activities