npj Precision Oncology (Sep 2021)
Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa
- Samuel Terkper Ahuno,
- Anna-Lisa Doebley,
- Thomas U. Ahearn,
- Joel Yarney,
- Nicholas Titiloye,
- Nancy Hamel,
- Ernest Adjei,
- Joe-Nat Clegg-Lamptey,
- Lawrence Edusei,
- Baffour Awuah,
- Xiaoyu Song,
- Verna Vanderpuye,
- Mustapha Abubakar,
- Maire Duggan,
- Daniel G. Stover,
- Kofi Nyarko,
- John M. S. Bartlett,
- Francis Aitpillah,
- Daniel Ansong,
- Kevin L. Gardner,
- Felix Andy Boateng,
- Anne M. Bowcock,
- Carlos Caldas,
- William D. Foulkes,
- Seth Wiafe,
- Beatrice Wiafe-Addai,
- Montserrat Garcia-Closas,
- Alexander Kwarteng,
- Gavin Ha,
- Jonine D. Figueroa,
- Paz Polak,
- the Ghana Breast Health Study Team
Affiliations
- Samuel Terkper Ahuno
- Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology
- Anna-Lisa Doebley
- Molecular and Cellular Biology Program, University of Washington
- Thomas U. Ahearn
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Joel Yarney
- Korle Bu Teaching Hospital
- Nicholas Titiloye
- Komfo Anokye Teaching Hospital
- Nancy Hamel
- Research Institute of the McGill University Health Centre
- Ernest Adjei
- Komfo Anokye Teaching Hospital
- Joe-Nat Clegg-Lamptey
- Korle Bu Teaching Hospital
- Lawrence Edusei
- Korle Bu Teaching Hospital
- Baffour Awuah
- Komfo Anokye Teaching Hospital
- Xiaoyu Song
- Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York City
- Verna Vanderpuye
- Korle Bu Teaching Hospital
- Mustapha Abubakar
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Maire Duggan
- Department of Pathology and Laboratory Medicine, University of Calgary
- Daniel G. Stover
- Stefanie Spielman Comprehensive Breast Cancer, The Ohio State University
- Kofi Nyarko
- University of Ghana
- John M. S. Bartlett
- Ontario Institute for Cancer Research
- Francis Aitpillah
- Komfo Anokye Teaching Hospital
- Daniel Ansong
- Department of Child Health, Kwame Nkrumah University of Science and Technology
- Kevin L. Gardner
- Department of Pathology and Cell Biology, Columbia University Medical Center, New York
- Felix Andy Boateng
- Komfo Anokye Teaching Hospital
- Anne M. Bowcock
- Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City
- Carlos Caldas
- Cancer Research UK Cambridge Centre
- William D. Foulkes
- Research Institute of the McGill University Health Centre
- Seth Wiafe
- School of Public Health, Loma Linda University
- Beatrice Wiafe-Addai
- Peace and Love Hospital
- Montserrat Garcia-Closas
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Alexander Kwarteng
- Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology
- Gavin Ha
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Jonine D. Figueroa
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Paz Polak
- Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City
- the Ghana Breast Health Study Team
- DOI
- https://doi.org/10.1038/s41698-021-00219-7
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 8
Abstract
Abstract Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.
