Nature Communications (Jul 2022)
Orexin neurons inhibit sleep to promote arousal
- Roberto De Luca,
- Stefano Nardone,
- Kevin P. Grace,
- Anne Venner,
- Michela Cristofolini,
- Sathyajit S. Bandaru,
- Lauren T. Sohn,
- Dong Kong,
- Takatoshi Mochizuki,
- Bianca Viberti,
- Lin Zhu,
- Antonino Zito,
- Thomas E. Scammell,
- Clifford B. Saper,
- Bradford B. Lowell,
- Patrick M. Fuller,
- Elda Arrigoni
Affiliations
- Roberto De Luca
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Stefano Nardone
- Department of Medicine, Division of Endocrinology, Diabetes and Metabolism. Beth Israel Deaconess Medical Center and Harvard Medical School
- Kevin P. Grace
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Anne Venner
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Michela Cristofolini
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Sathyajit S. Bandaru
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Lauren T. Sohn
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Dong Kong
- Department of Pediatrics, Division of Endocrinology, F.M. Kirby Neurobiology Center. Children’s Hospital and Harvard Medical School
- Takatoshi Mochizuki
- Department of Biology, Graduate School of Science and Engineering. University of Toyama
- Bianca Viberti
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Lin Zhu
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Antonino Zito
- Department of Molecular Biology, Massachusetts General Hospital
- Thomas E. Scammell
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Clifford B. Saper
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Bradford B. Lowell
- Department of Medicine, Division of Endocrinology, Diabetes and Metabolism. Beth Israel Deaconess Medical Center and Harvard Medical School
- Patrick M. Fuller
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- Elda Arrigoni
- Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-022-31591-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Sleep and wakefulness is stabilized by a population of orexin-expressing neurons. In this study, the authors demonstrate how these neurons drive arousal by silencing sleep-promoting neurons in the ventrolateral preoptic nucleus.
