Identification of essential genes in <i>Caenorhabditis elegans</i> through whole-genome sequencing of legacy mutant collections

Affiliations

Erica Li-Leger: Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
Richard Feichtinger: Department of Developmental Genetics, Institute of Genetics, Technische Universität, Braunschweig 38106, Germany
Stephane Flibotte: UBC/LSI Bioinformatics Facility, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
Heinke Holzkamp: Department of Developmental Genetics, Institute of Genetics, Technische Universität, Braunschweig 38106, Germany
Ralf Schnabel: Department of Developmental Genetics, Institute of Genetics, Technische Universität, Braunschweig 38106, Germany
Donald G Moerman: Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada

Abstract

AbstractIt has been estimated that 15%–30% of the ∼20,000 genes in C. elegansC. elegans