Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique

Yang-Yang Liu; De-Li Chen; Jian-He Wei; Jian Feng; Zheng Zhang; Yun Yang; Wei Zheng

doi:10.3390/molecules21111433

Molecules (Oct 2016)

Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique

Yang-Yang Liu,
De-Li Chen,
Jian-He Wei,
Jian Feng,
Zheng Zhang,
Yun Yang,
Wei Zheng

Affiliations

Yang-Yang Liu: Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
De-Li Chen: Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China
Jian-He Wei: Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Jian Feng: Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China
Zheng Zhang: Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Yun Yang: Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Wei Zheng: Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China

DOI: https://doi.org/10.3390/molecules21111433
Journal volume & issue: Vol. 21, no. 11
p. 1433

Abstract

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Four new 2-(2-phenylethyl)chromone derivatives (1–4) were isolated from the EtOH extract of Chinese agarwood produced via the whole-tree agarwood-inducing technique, coming from Aquilaria sinensis (Lour.) Spreng. (Thymelaeaceae). Their structures were elucidated by extensive spectroscopic methods, such as UV, IR, MS, 1D as well as 2D NMR. All of the isolates were then assessed for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7. Compound 1 exhibited significant inhibitory activity with an IC50 value of 4.6 μM.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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