Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates

Davide Simone; Frank Penkava; Anna Ridley; Stephen Sansom; M. Hussein Al-Mossawi; Paul Bowness

doi:10.1038/s42003-021-02931-3

Communications Biology (Dec 2021)

Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates

Davide Simone,
Frank Penkava,
Anna Ridley,
Stephen Sansom,
M. Hussein Al-Mossawi,
Paul Bowness

Affiliations

Davide Simone: Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
Frank Penkava: Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
Anna Ridley: Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
Stephen Sansom: Kennedy Institute of Rheumatology, University of Oxford
M. Hussein Al-Mossawi: Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford
Paul Bowness: Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford

DOI: https://doi.org/10.1038/s42003-021-02931-3
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

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Simone et al. analyze T cell receptor usage and gene expression profiles of CD3+CD45RA-CD25+CD127low blood and synovial fluid regulatory T cells from patients with spondyloarthritis. This work provides a valuable resource for understanding regulatory T cell heterogeneity and transcriptional adaptation in an immune-driven condition.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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