Clinical and endocrine characteristics of the menstrual cycle of women

Abstract

The literature data is systematization and presentation of the most relevant factors and mechanisms in clinical and hormonal characteristics of the menstrual cycle during a natural transition to menopause. The emergence of luteal out-of-phase LOOP event is a consequence of cyclic stimulation preantral follicles that become sensitive to stimulationof follicle-stimulating hormone in certain intervals of the menstrual cycle. These intervals describe as reflexive waves that occur within one menstrual period in women menopausal transition. The LOOP phenomenon explains the nature of variable endocrine changes during the transition to menopause.

Keywords

• menstrual cycle
• menopausal transition
• atypical estradiol secretion