Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity

Juan Tang; Guoxin Lin; Guoxin Lin; Wallace Y. Langdon; Lijian Tao; Jian Zhang

doi:10.3389/fimmu.2018.00123

Frontiers in Immunology (Feb 2018)

Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity

Juan Tang,
Guoxin Lin,
Guoxin Lin,
Wallace Y. Langdon,
Lijian Tao,
Jian Zhang

Affiliations

Juan Tang: Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Guoxin Lin: Department of Pathology, The University of Iowa, Iowa City, IA, United States
Guoxin Lin: Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China
Wallace Y. Langdon: School of Biological Sciences, University of Western Australia, Perth, WA, Australia
Lijian Tao: Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Jian Zhang: Department of Pathology, The University of Iowa, Iowa City, IA, United States

DOI: https://doi.org/10.3389/fimmu.2018.00123
Journal volume & issue: Vol. 9

Abstract

Read online

Of all the pathogen recognition receptor families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of antifungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated-signaling pathways. In this review, we highlight novel insights in antifungal innate and adaptive-protective immunity mediated by CLRs and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

About the journal

Abstract

Keywords