Nature Communications (Jul 2021)
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development
- Jianli He,
- Xun Shangguan,
- Wei Zhou,
- Ying Cao,
- Quan Zheng,
- Jun Tu,
- Gaolei Hu,
- Zi Liang,
- Cen Jiang,
- Liufu Deng,
- Shengdian Wang,
- Wen Yang,
- Yong Zuo,
- Jiao Ma,
- Rong Cai,
- Yalan Chen,
- Qiuju Fan,
- Baijun Dong,
- Wei Xue,
- Hongsheng Tan,
- Yitao Qi,
- Jianmin Gu,
- Bing Su,
- Y. Eugene Chin,
- Guoqiang Chen,
- Qi Wang,
- Tianshi Wang,
- Jinke Cheng
Affiliations
- Jianli He
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Xun Shangguan
- Department of Urology, Renji Hospital Affiliated, Shanghai Jiao Tong University School of Medicine
- Wei Zhou
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Ying Cao
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Quan Zheng
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Jun Tu
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Gaolei Hu
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Zi Liang
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Cen Jiang
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Liufu Deng
- Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Shengdian Wang
- Institute of Biophysics, Chinese Academy of Sciences
- Wen Yang
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Yong Zuo
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Jiao Ma
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Rong Cai
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Yalan Chen
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Qiuju Fan
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Baijun Dong
- Department of Urology, Renji Hospital Affiliated, Shanghai Jiao Tong University School of Medicine
- Wei Xue
- Department of Urology, Renji Hospital Affiliated, Shanghai Jiao Tong University School of Medicine
- Hongsheng Tan
- Clinical Research Center, Shanghai Jiao Tong University School of Medicine
- Yitao Qi
- College of Life Sciences, Shaanxi Normal University
- Jianmin Gu
- Department of Thoracic Surgery, Zhongshan Hospital, Fudan University
- Bing Su
- Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine
- Y. Eugene Chin
- Institutes of Biology and Medical Sciences, Soochow University Medical College
- Guoqiang Chen
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Qi Wang
- Department of Urology, Renji Hospital Affiliated, Shanghai Jiao Tong University School of Medicine
- Tianshi Wang
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- Jinke Cheng
- State Key Laboratory of Oncogenes and Related Genes, Renji Hospital Affiliated; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-24619-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Memory T cells are particularly reliant on fatty acid oxidation as a source of energy. Here the authors show this reliance is controlled by AMPK sensing of glucose deprivation that triggers SENP1-Sirt3 signalling, driving fatty acid oxidation and memory differentiation in T cells via deacetylation of YME1L1 to induce mitochondrial fusion.
