ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation

Piotr Przanowski; Róża K. Przanowska; Michael J. Guertin

doi:10.1038/s42003-023-04611-w

Communications Biology (Mar 2023)

ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation

Piotr Przanowski,
Róża K. Przanowska,
Michael J. Guertin

Affiliations

Piotr Przanowski: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine
Róża K. Przanowska: Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine
Michael J. Guertin: Center for Cell Analysis and Modeling, University of Connecticut

DOI: https://doi.org/10.1038/s42003-023-04611-w
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 13

Abstract

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Ankyrin repeat and LEM-domain containing protein 1 (ANKLE1) cleaves the mitochondrial genome during erythropoiesis and ectopic expression of ANKLE1 promotes genome instability and apoptotic resistance, which contributes to breast cancer risk.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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