Diabetes, Metabolic Syndrome and Obesity (Apr 2023)

Gender-Specific Association of Handgrip Strength with Type 2 Diabetes Mellitus in Chinese Han Older Adults

  • Huang Q,
  • Chen X,
  • Shen HY,
  • Zhou JM,
  • Zhang HQ,
  • Wang L,
  • Chen R,
  • Cheng J,
  • Zhang Y,
  • Zhang DM,
  • Chen GM

Journal volume & issue
Vol. Volume 16
pp. 913 – 923

Abstract

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Qian Huang,1,* Xing Chen,1,2,* Hui Yan Shen,1 Jia Mou Zhou,1 He Qiao Zhang,1 Li Wang,1 Ren Chen,1 Jing Cheng,1 Yan Zhang,1 Dong Mei Zhang,1 Gui Mei Chen1 1School of Health Service Management, Anhui Medical University, Hefei, Anhui Province, People’s Republic of China; 2School of Public Health, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gui Mei Chen; Dong Mei Zhang, Email [email protected]; [email protected]: We aimed to analyze the relationship between handgrip strength/relative handgrip strength among older Han adults with type 2 diabetes mellitus (T2DM) by gender to determine the optimal cut-off value of grip strength for older adults.Methods: A multi-stage sampling method was used to conduct a questionnaire survey and physical examination of 6128 older adults in Anhui Province. Chi-squares tests, t-tests, analysis of variance, and logistic regression analysis were used to analyze the association between handgrip strength/relative handgrip strength and T2DM between the sexes. The decision tree model (CRT) was used to explore the predictive value of handgrip strength /relative handgrip strength on T2DM.Results: There was an association between handgrip strength and T2DM (P = 0.006, OR = 0.985, 95% CI = 0.975, 0.996), which was found in females (P = 0.013, OR = 0.978, 95% CI = 0.961, 0.995) but not in males (P = 0.125, OR = 0.989, 95% CI = 0.976, 1.003). Relative handgrip strength was also correlated with T2DM (P = 0.014, OR = 0.730, 95% CI = 0.568, 0.939), which was found in females (P = 0.003, OR = 0.534, 95% CI = 0.352, 0.809) but not in males (P = 0.432, OR = 0.879, 95% CI = 0.638, 1.212). The incidence of T2DM in elderly females with hypertension who were uneducated and with a handgrip strength of < 17.350 kg was 24.3% (115 cases), whereas that in elderly females with hypertension and a relative handgrip strength of < 0.240 was 29.0% (127 cases).Conclusion: According to our results, handgrip strength and relative handgrip strength were associated with T2DM. People with hypertension had a higher risk of T2DM in women with a handgrip strength of ≤ 17.350kg and a relative grip strength of ≤ 0.240. Further research is needed to validate the effectiveness of this cut-off for implementing interventions and avoiding risks.Keywords: diabetes mellitus, handgrip strength, gender, older adult

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