The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

Kentaro Hosokawa; Ben D. MacArthur; Yoshiko Matsumoto Ikushima; Hirofumi Toyama; Yoshikazu Masuhiro; Shigemasa Hanazawa; Toshio Suda; Fumio Arai

doi:10.1038/s41467-017-00935-4

Nature Communications (Oct 2017)

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

Kentaro Hosokawa,
Ben D. MacArthur,
Yoshiko Matsumoto Ikushima,
Hirofumi Toyama,
Yoshikazu Masuhiro,
Shigemasa Hanazawa,
Toshio Suda,
Fumio Arai

Affiliations

Kentaro Hosokawa: Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University
Ben D. MacArthur: Centre for Human Development, Stem Cells and Regeneration, Faculty of Medicine, University of Southampton
Yoshiko Matsumoto Ikushima: Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University
Hirofumi Toyama: Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University
Yoshikazu Masuhiro: Laboratory of Molecular and Cellular Physiology, Department of Applied Biological Sciences, College of Bioresource Sciences, Nihon University
Shigemasa Hanazawa: Laboratory of Molecular and Cellular Physiology, Department of Applied Biological Sciences, College of Bioresource Sciences, Nihon University
Toshio Suda: Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University
Fumio Arai: Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University

DOI: https://doi.org/10.1038/s41467-017-00935-4
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensitive to this damage. Here, the authors show in murine HSCs that the telomere binding protein POT1a inhibited the production of reactive oxygen species, and rejuvenated aged HSCs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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