Journal of Vascular Surgery Cases and Innovative Techniques (Dec 2022)

Regression of a venous malformation during angiotensin-converting enzyme inhibitor treatment for hypertension

  • Sigurd Berger, MD,
  • Therese Halvorsen Bjark, MD,
  • Karsten Midtvedt, MD, PhD,
  • Rune Andersen, MD

Journal volume & issue
Vol. 8, no. 4
pp. 657 – 659

Abstract

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Recent studies have reported that components of the renin-angiotensin system (RAS) are expressed in venous malformations by embryonic stem cell-like subpopulations. It has been hypothesized that these cells are sustained by the RAS and, therefore, could be a novel therapeutic target, using medications such as angiotensin-converting enzyme inhibitors. A young man with a symptomatic intramuscular venous malformation of the upper limb, and hypertension was treated with an angiotensin-converting enzyme inhibitor. After 8 months of treatment, we registered a considerable volume reduction of the venous malformation and a reduction in pain. Our observation warrants further research on the link between the RAS and venous malformations.

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