Nature Communications (Apr 2016)
FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
- Felipe Slebe,
- Federico Rojo,
- Maria Vinaixa,
- Mar García-Rocha,
- Giorgia Testoni,
- Marc Guiu,
- Evarist Planet,
- Sara Samino,
- Enrique J. Arenas,
- Antoni Beltran,
- Ana Rovira,
- Ana Lluch,
- Xavier Salvatella,
- Oscar Yanes,
- Joan Albanell,
- Joan J. Guinovart,
- Roger R. Gomis
Affiliations
- Felipe Slebe
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Federico Rojo
- Cancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)
- Maria Vinaixa
- Centre for Omic Sciences, Universitat Rovira i Virgili
- Mar García-Rocha
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Giorgia Testoni
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Marc Guiu
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Evarist Planet
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Sara Samino
- Centre for Omic Sciences, Universitat Rovira i Virgili
- Enrique J. Arenas
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Antoni Beltran
- Centre for Omic Sciences, Universitat Rovira i Virgili
- Ana Rovira
- Cancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)
- Ana Lluch
- Medical Oncology Service, Hospital Clinico
- Xavier Salvatella
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Oscar Yanes
- Centre for Omic Sciences, Universitat Rovira i Virgili
- Joan Albanell
- Cancer Research Programme, IMIM (Hospital del Mar Medical Research Institute)
- Joan J. Guinovart
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Roger R. Gomis
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- DOI
- https://doi.org/10.1038/ncomms11199
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
Deregulation of lipid metabolism in cancer cells is critical to the maintenance of certain malignant features. Here, the authors show that the proliferation of breast cancer cells depends upon the extracellular activity of the endothelial lipase enzyme LIPG whose expression is regulated by the FoxA family of transcription factors.
