Global landscape of replicative DNA polymerase usage in the human genome

Eri Koyanagi; Yoko Kakimoto; Tamiko Minamisawa; Fumiya Yoshifuji; Toyoaki Natsume; Atsushi Higashitani; Tomoo Ogi; Antony M. Carr; Masato T. Kanemaki; Yasukazu Daigaku

doi:10.1038/s41467-022-34929-8

Nature Communications (Nov 2022)

Global landscape of replicative DNA polymerase usage in the human genome

Eri Koyanagi,
Yoko Kakimoto,
Tamiko Minamisawa,
Fumiya Yoshifuji,
Toyoaki Natsume,
Atsushi Higashitani,
Tomoo Ogi,
Antony M. Carr,
Masato T. Kanemaki,
Yasukazu Daigaku

Affiliations

Eri Koyanagi: Frontier Research Institute for Interdisciplinary Sciences, Tohoku University
Yoko Kakimoto: Frontier Research Institute for Interdisciplinary Sciences, Tohoku University
Tamiko Minamisawa: Cancer Genome Dynamics project, Cancer Institute, Japanese Foundation for Cancer Research
Fumiya Yoshifuji: Graduate School of Life Sciences, Tohoku University
Toyoaki Natsume: National Institute of Genetics, Research Organization of Information and Systems (ROIS)
Atsushi Higashitani: Graduate School of Life Sciences, Tohoku University
Tomoo Ogi: Research Institute of Environmental Medicine, Nagoya University
Antony M. Carr: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Masato T. Kanemaki: National Institute of Genetics, Research Organization of Information and Systems (ROIS)
Yasukazu Daigaku: Frontier Research Institute for Interdisciplinary Sciences, Tohoku University

DOI: https://doi.org/10.1038/s41467-022-34929-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

Read online

Profiling of human DNA polymerase Polε and Polα demonstrates their roles in leading and lagging strand DNA synthesis, and their independent measures allowed accurate predictions of replication dynamics and effects of transcription.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal