Einstein (São Paulo) ()

Lipid profile and statin use in critical care setting: implications for kidney outcome

  • Isabelle Malbouisson,
  • Beata Marie Quinto,
  • Marcelino de Souza Durão Junior,
  • Júlio Cesar Martins Monte,
  • Oscar Fernando Pavão dos Santos,
  • Roberto Camargo Narciso,
  • Maria Aparecida Dalboni,
  • Marcelo Costa Batista

DOI
https://doi.org/10.31744/einstein_journal/2019ao4399
Journal volume & issue
Vol. 17, no. 3

Abstract

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ABSTRACT Objective: To determine whether pre-hospital statin use is associated with lower renal replacement therapy requirement and/or death during intensive care unit stay. Methods: Prospective cohort analysis. We analyzed 670 patients consecutively admitted to the intensive care unit of an academic tertiary-care hospital. Patients with ages ranging from 18 to 80 years admitted to the intensive care unit within the last 48 hours were included in the study. Results: Mean age was 66±16.1 years old, mean body mass index 26.6±4/9kg/m2 and mean abdominal circumference was of 97±22cm. The statin group comprised 18.2% of patients and had lower renal replacement therapy requirement and/or mortality (OR: 0.41; 95%CI: 0.18-0.93; p=0.03). The statin group also had lower risk of developing sepsis during intensive care unit stay (OR: 0.42; 95%CI: 0.22-0.77; p=0.006) and had a reduction in hospital length-of-stay (14.7±17.5 days versus 22.3±48 days; p=0.006). Statin therapy was associated with a protective role in critical care setting independently of confounding variables, such as gender, age, C-reactive protein, need of mechanical ventilation, use of pressor agents and presence of diabetes and/or coronary disease. Conclusion: Statin therapy prior to hospital admission was associated with lower mortality, lower renal replacement therapy requirement and sepsis rates.

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