The effect of lipocortin 1 on neutrophil deformability

E. M. Drost; W.  MacNee; S. F. Smith

doi:10.1155/S0962935196000257

Mediators of Inflammation (Jan 1996)

The effect of lipocortin 1 on neutrophil deformability

E. M. Drost,
W. MacNee,
S. F. Smith

Affiliations

E. M. Drost: Department of Medicine, Rayne Laboratory, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
W. MacNee: Department of Medicine, Rayne Laboratory, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
S. F. Smith: Department of Medicine, Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, UK

DOI: https://doi.org/10.1155/S0962935196000257
Journal volume & issue: Vol. 5, no. 3
pp. 188 – 190

Abstract

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Lipocortn 1 (Lc1) is an anti-inflammatory protein, which, given systemically, inhibits polymorphonuclear neutrophil (PMN) emigration from the circulation to sites of inflammation; delivery of Lc1 to the inflamed site is ineffective. We have examined the effect of Lc1 on changes in PMN deformability, and observed a consistent improvement in the deformability of unstimulated PMN; N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated cell deformability was unaltered. A Lc1-induced increase in cell deformability may reduce PMN sequestration so contributing to the anti-migratory effects of systemic Lc1 previously demonstrated in vivo.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://www.hindawi.com/journals/mi/

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