BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis

Malay Mandal; Mark Maienschein-Cline; Patrick Maffucci; Margaret Veselits; Domenick E. Kennedy; Kaitlin C. McLean; Michael K. Okoreeh; Sophiya Karki; Charlotte Cunningham-Rundles; Marcus R. Clark

doi:10.1038/s41467-018-06165-6

Nature Communications (Sep 2018)

BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis

Malay Mandal,
Mark Maienschein-Cline,
Patrick Maffucci,
Margaret Veselits,
Domenick E. Kennedy,
Kaitlin C. McLean,
Michael K. Okoreeh,
Sophiya Karki,
Charlotte Cunningham-Rundles,
Marcus R. Clark

Affiliations

Malay Mandal: Department of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago
Mark Maienschein-Cline: Core for Research Informatics, University of Illinois at Chicago
Patrick Maffucci: Immunology Institute, Icahn School of Medicine at Mount Sinai
Margaret Veselits: Department of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago
Domenick E. Kennedy: Department of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago
Kaitlin C. McLean: Department of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago
Michael K. Okoreeh: Department of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago
Sophiya Karki: Department of Research Biology, Genentech, South San Francisco
Charlotte Cunningham-Rundles: Immunology Institute, Icahn School of Medicine at Mount Sinai
Marcus R. Clark: Department of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago

DOI: https://doi.org/10.1038/s41467-018-06165-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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B-cell development is tightly regulated by transcription programs that are coordinated by transcription factors (TF) and locus accessibility. Here the authors show that, in mice and humans, the epigenetic reader BRWD1 inhibits and promotes the accessibility of enhancers for early and late B lymphopoiesis, respectively.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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