Nature Communications (Jan 2019)
Venous identity requires BMP signalling through ALK3
- Alice Neal,
- Svanhild Nornes,
- Sophie Payne,
- Marsha D. Wallace,
- Martin Fritzsche,
- Pakavarin Louphrasitthiphol,
- Robert N. Wilkinson,
- Kira M. Chouliaras,
- Ke Liu,
- Karen Plant,
- Radhika Sholapurkar,
- Indrika Ratnayaka,
- Wiebke Herzog,
- Gareth Bond,
- Tim Chico,
- George Bou-Gharios,
- Sarah De Val
Affiliations
- Alice Neal
- Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford
- Svanhild Nornes
- Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford
- Sophie Payne
- Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford
- Marsha D. Wallace
- Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford
- Martin Fritzsche
- Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford
- Pakavarin Louphrasitthiphol
- Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford
- Robert N. Wilkinson
- Department of Infection, Immunity and Cardiovascular Disease and Bateson Centre, University of Sheffield
- Kira M. Chouliaras
- Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford
- Ke Liu
- Institute of Aging and Chronic Disease, University of Liverpool
- Karen Plant
- Department of Infection, Immunity and Cardiovascular Disease and Bateson Centre, University of Sheffield
- Radhika Sholapurkar
- Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford
- Indrika Ratnayaka
- Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford
- Wiebke Herzog
- University of Muenster
- Gareth Bond
- Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford
- Tim Chico
- Department of Infection, Immunity and Cardiovascular Disease and Bateson Centre, University of Sheffield
- George Bou-Gharios
- Institute of Aging and Chronic Disease, University of Liverpool
- Sarah De Val
- Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-019-08315-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
The establishment of functional vasculatures requires the specification of newly formed vessels into veins and arteries. Here, Neal et al. use a combination of genetic approaches in mice and zebrafish to show that BMP signalling, via ALK3 and SMAD1/5, is required for venous specification during blood vessel development.
