Daily adaptive proton therapy: Feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton–boron fusion reaction

Min-Geon Choi; Martin Law; Shin-Kien Djeng; Moo-Sub Kim; Han-Back Shin; Bo-Young Choe; Do-Kun Yoon; Tae Suk Suh

Nuclear Engineering and Technology (Aug 2022)

Daily adaptive proton therapy: Feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton–boron fusion reaction

Min-Geon Choi,
Martin Law,
Shin-Kien Djeng,
Moo-Sub Kim,
Han-Back Shin,
Bo-Young Choe,
Do-Kun Yoon,
Tae Suk Suh

Affiliations

Min-Geon Choi: Department of Biomedicine & Health Science and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, 505, South Korea
Martin Law: Proton Therapy Pte Ltd., 1 Biopolis Drive, 138622, Singapore
Shin-Kien Djeng: Proton Therapy Pte Ltd., 1 Biopolis Drive, 138622, Singapore
Moo-Sub Kim: Department of Biomedicine & Health Science and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, 505, South Korea
Han-Back Shin: Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, 03722, South Korea
Bo-Young Choe: Department of Biomedicine & Health Science and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, 505, South Korea
Do-Kun Yoon: Department of Biomedicine & Health Science and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, 505, South Korea; Corresponding author.
Tae Suk Suh: Department of Biomedicine & Health Science and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, 505, South Korea; Corresponding author.

Journal volume & issue: Vol. 54, no. 8
pp. 3006 – 3016

Abstract

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In this study, the images of specific prompt gamma (PG)-rays of 719 keV emitted from proton–boron reactions were analyzed using single-photon emission computed tomography (SPECT). Quantitative evaluation of the images verified the detection of anatomical changes in tumors, one of the important factors in daily adaptive proton therapy (DAPT) and verified the possibility of application of the PG-ray images to DAPT. Six scenarios were considered based on various sizes and locations compared to the reference virtual tumor to observe the anatomical alterations in the virtual tumor. Subsequently, PG-rays SPECT images were acquired using the modified ordered subset expectation-maximization algorithm, and these were evaluated using quantitative analysis methods. The results confirmed that the pixel range and location of the highest value of the normalized pixel in the PG-rays SPECT image profile changed according to the size and location of the virtual tumor. Moreover, the alterations in the virtual tumor size and location in the PG-rays SPECT images were similar to the true size and location alterations set in the phantom. Based on the above results, the tumor anatomical alterations in DAPT could be adequately detected and verified through SPECT imaging using the 719 keV PG-rays acquired during treatment.

Published in Nuclear Engineering and Technology

ISSN: 1738-5733 (Print)
Publisher: Elsevier
Country of publisher: Korea, Republic of
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Nuclear engineering. Atomic power
Website: http://www.journals.elsevier.com/nuclear-engineering-and-technology

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