Ritter-type amination of C(sp3)-H bonds enabled by electrochemistry with SO4 2−

Ling Zhang; Youtian Fu; Yi Shen; Chengyu Liu; Maolin Sun; Ruihua Cheng; Weiping Zhu; Xuhong Qian; Yueyue Ma; Jinxing Ye

doi:10.1038/s41467-022-31813-3

Nature Communications (Jul 2022)

Ritter-type amination of C(sp3)-H bonds enabled by electrochemistry with SO4 2−

Ling Zhang,
Youtian Fu,
Yi Shen,
Chengyu Liu,
Maolin Sun,
Ruihua Cheng,
Weiping Zhu,
Xuhong Qian,
Yueyue Ma,
Jinxing Ye

Affiliations

Ling Zhang: Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
Youtian Fu: Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
Yi Shen: Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
Chengyu Liu: Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
Maolin Sun: School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology
Ruihua Cheng: School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology
Weiping Zhu: State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology
Xuhong Qian: State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology
Yueyue Ma: School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology
Jinxing Ye: Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology

DOI: https://doi.org/10.1038/s41467-022-31813-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

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The amination of C(sp3)–H bonds is an appealing and challenging task in organic synthesis. Here, by using an electrogenerated sulfate radical an HAT agent, the authors report a practical Ritter-type amination of C(sp3)–H bonds.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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