Nature Communications (Mar 2023)

Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma

  • Ana Portelinha,
  • Mariana da Silva Ferreira,
  • Tatiana Erazo,
  • Man Jiang,
  • Zahra Asgari,
  • Elisa de Stanchina,
  • Anas Younes,
  • Hans-Guido Wendel

DOI
https://doi.org/10.1038/s41467-023-37216-2
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 13

Abstract

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Genomic instability occurs infrequently in in diffuse large B cell lymphoma (DLBCL), suggesting a therapeutic vulnerability. Here, the authors identify a synergistic combination between the induction of polyploidy by a PLK4 inhibitor and a BCL-2 inhibitor in DLBCL.