Nature Communications (Jul 2019)

Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise

  • Jörn M. Schmiedel,
  • Lucas B. Carey,
  • Ben Lehner

DOI
https://doi.org/10.1038/s41467-019-11116-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Quantifying the effects of noise in gene expression is difficult since noise and mean expression are coupled. Here the authors determine fitness landscapes in mean-noise expression space to uncouple these two parameters and show that changes in noise and mean expression are similarly detrimental to fitness.