Diabetes, Metabolic Syndrome and Obesity (Dec 2020)

Interactive Effect of IGF2BP2 rs4402960 Variant, Smoking and Type 2 Diabetes

  • Nfor ON,
  • Ndzinisa NB,
  • Tsai MH,
  • Hsiao CH,
  • Liaw YP

Journal volume & issue
Vol. Volume 13
pp. 5097 – 5102

Abstract

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Oswald Ndi Nfor,1 Nokuphila Balindile Ndzinisa,1 Meng‑Hsiun Tsai,2 Chih-Hsuan Hsiao,1 Yung-Po Liaw1,3 1Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City 40201, Taiwan; 2Department of Management Information Systems, National Chung Hsing University, Taichung, Taiwan; 3Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City 40201, TaiwanCorrespondence: Yung-Po LiawDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110, Sec. 1 Jianguo N. Road, Taichung City 40201, TaiwanTel +886-4-24730022 ext.11838Fax +886-4-23248179Email [email protected]: Genetic and environmental factors are related to type 2 diabetes (T2D). Genetic modifiers of T2D have not been widely determined among smoking individuals. In this population-based study, we investigated the interactive association between rs4402960 polymorphism of the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) gene and smoking with T2D among Taiwanese adults.Materials and Methods: We obtained genetic data collected between 2008 and 2018 for 22,039 participants (aged 30– 70 years) from the Taiwan Biobank (TWB) database. These data were analyzed using the t-test, Chi-square (χ2) test, and multiple logistic regression.Results: The mean ages for participants with and without diabetes were 58.11± 8.75 and 48.58± 11, respectively. Compared with the rs4402960 GG genotype, the odds ratio (OR) for T2D was 1.261 among GT and 1.545 among TT genotype individuals (p< 0.05). Current smokers compared to nonsmokers were associated with a higher risk of T2D (OR=1.266, p=0.0404). There was a significant interaction between the IGF2BP2 rs4402960 variant and smoking on T2D (p = 0.0497). After stratification by rs4402960 genotypes and smoking status, the OR was substantial only in current smokers with GG genotype (OR, 1.663, p = 0.0008).Conclusion: This population-based study indicated that the risk for T2D was stronger among current smoking rs4402960 GG individuals recruited between 2008 and 2019 in Taiwan.Keywords: polymorphism, metabolic syndrome, lifestyle, diabetes

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