The influence of osteoporosis on mechanical complications in lumbar fusion surgery: a systematic review

Anna Filley, MD; Avionna Baldwin, MD; Alma Rechav Ben-Natan; Keith Hansen, MD; Ayush Arora; Angel Xiao, MD, MSE; Deana Hammond, RDMS, RMSKS; Caressa Chen, MD; Isobel Tweedt; James Rohde; Thomas Link, MD, PhD; Sigurd Berven, MD; Aenor Sawyer, MD, MS

North American Spine Society Journal (Jun 2024)

The influence of osteoporosis on mechanical complications in lumbar fusion surgery: a systematic review

Anna Filley, MD,
Avionna Baldwin, MD,
Alma Rechav Ben-Natan,
Keith Hansen, MD,
Ayush Arora,
Angel Xiao, MD, MSE,
Deana Hammond, RDMS, RMSKS,
Caressa Chen, MD,
Isobel Tweedt,
James Rohde,
Thomas Link, MD, PhD,
Sigurd Berven, MD,
Aenor Sawyer, MD, MS

Affiliations

Anna Filley, MD: Department of Orthopaedic Surgery, University of California, 435 Warren Drive, Apt 11, San Francisco, CA, USA; Corresponding author: Department of Orthopaedic Surgery, University of California, 435 Warren Drive, Apt 11, San Francisco, CA 94131, USA. Tel.: 765-414-7338.
Avionna Baldwin, MD: Department of Orthopaedic Surgery, University of California, 435 Warren Drive, Apt 11, San Francisco, CA, USA
Alma Rechav Ben-Natan: Department of Neurological Surgery, University of California, San Francisco, CA, USA
Keith Hansen, MD: Department of General Surgery, University of California, San Francisco, CA, USA
Ayush Arora: Department of Orthopaedic Surgery, University of California, 435 Warren Drive, Apt 11, San Francisco, CA, USA
Angel Xiao, MD, MSE: Department of Orthopaedic Surgery, University of California, 435 Warren Drive, Apt 11, San Francisco, CA, USA
Deana Hammond, RDMS, RMSKS: Department of Orthopaedic Surgery, University of California, 435 Warren Drive, Apt 11, San Francisco, CA, USA
Caressa Chen, MD: Loyola University Medical Center; Maywood IL, USA
Isobel Tweedt: Department of Orthopaedic Surgery, University of California, 435 Warren Drive, Apt 11, San Francisco, CA, USA; Western University of Health Sciences College of Osteopathic Medicine of the Pacific, USA
James Rohde: Department of Integrative Biology, University of California Berkeley, USA
Thomas Link, MD, PhD: Department of Radiology and Biomedical Imagery, University of California, San Francisco, CA, USA
Sigurd Berven, MD: Department of Orthopaedic Surgery, University of California, 435 Warren Drive, Apt 11, San Francisco, CA, USA
Aenor Sawyer, MD, MS: Department of Orthopaedic Surgery, University of California, 435 Warren Drive, Apt 11, San Francisco, CA, USA

Journal volume & issue: Vol. 18
p. 100327

Abstract

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Background: Adults undergoing spine surgery often have underlying osteoporosis, which may be a risk factor for postoperative complications. Although these associations have been described, osteoporosis remains profoundly underdiagnosed and undertreated in the spine surgery population. A thorough, comprehensive systematic review summarizing the relationships between bone mineral density (BMD) and specific complications of lumbar fusion surgery could be a valuable resource for raising awareness and supporting clinical practice changes. Methods: PubMed, Embase, and Web of Science databases were searched for original clinical research articles reporting on BMD, or surrogate measure, as a predictor of complications in adults undergoing elective lumbar fusion for degenerative disease or deformity. Endpoints included cage subsidence, screw loosening, pseudarthrosis, vertebral fracture, junctional complications, and reoperation. Results: A total of 71 studies comprising 12,278 patients were included. Overall, considerable heterogeneity in study populations, methods of bone health assessment, and definition and evaluation of clinical endpoints precluded meta-analysis. Nevertheless, low BMD was associated with higher rates of implant failures like cage subsidence and screw loosening, which were often diagnosed with concomitant pseudarthrosis. Osteoporosis was also a significant risk factor for proximal junctional kyphosis, particularly due to fracture. Many studies found surgical site-specific BMD to best predict focal complications. Functional outcomes were inconsistently addressed. Conclusions: Our findings suggest osteoporosis is a significant risk factor for mechanical complications of lumbar fusion. These results emphasize the importance of preoperative osteoporosis screening, which allows for medical and surgical optimization of high-risk patients. This review also highlights current practical challenges facing bone health evaluation in patients undergoing elective surgery. Future prospective studies using standardized methods are necessary to strengthen existing evidence, identify optimal predictive thresholds, and establish specialty-specific practice guidelines. In the meantime, an awareness of the surgical implications of osteoporosis and utility of preoperative screening can provide for more informed, effective patient care.

Published in North American Spine Society Journal

ISSN: 2666-5484 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Surgery: Orthopedic surgery; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.journals.elsevier.com/north-american-spine-society-journal-nassj/

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