Nature Communications (Jan 2020)
Microscaled proteogenomic methods for precision oncology
- Shankha Satpathy,
- Eric J. Jaehnig,
- Karsten Krug,
- Beom-Jun Kim,
- Alexander B. Saltzman,
- Doug W. Chan,
- Kimberly R. Holloway,
- Meenakshi Anurag,
- Chen Huang,
- Purba Singh,
- Ari Gao,
- Noel Namai,
- Yongchao Dou,
- Bo Wen,
- Suhas V. Vasaikar,
- David Mutch,
- Mark A. Watson,
- Cynthia Ma,
- Foluso O. Ademuyiwa,
- Mothaffar F. Rimawi,
- Rachel Schiff,
- Jeremy Hoog,
- Samuel Jacobs,
- Anna Malovannaya,
- Terry Hyslop,
- Karl R. Clauser,
- D. R. Mani,
- Charles M. Perou,
- George Miles,
- Bing Zhang,
- Michael A. Gillette,
- Steven A. Carr,
- Matthew J. Ellis
Affiliations
- Shankha Satpathy
- Broad Institute of Harvard and Massachusetts Institute of Technology
- Eric J. Jaehnig
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Karsten Krug
- Broad Institute of Harvard and Massachusetts Institute of Technology
- Beom-Jun Kim
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Alexander B. Saltzman
- Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
- Doug W. Chan
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Kimberly R. Holloway
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Meenakshi Anurag
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Chen Huang
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Purba Singh
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Ari Gao
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Noel Namai
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Yongchao Dou
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Bo Wen
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Suhas V. Vasaikar
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- David Mutch
- Siteman Comprehensive Cancer Center and Washington University School of Medicine
- Mark A. Watson
- Siteman Comprehensive Cancer Center and Washington University School of Medicine
- Cynthia Ma
- Siteman Comprehensive Cancer Center and Washington University School of Medicine
- Foluso O. Ademuyiwa
- Siteman Comprehensive Cancer Center and Washington University School of Medicine
- Mothaffar F. Rimawi
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Rachel Schiff
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Jeremy Hoog
- Siteman Comprehensive Cancer Center and Washington University School of Medicine
- Samuel Jacobs
- NSABP Foundation
- Anna Malovannaya
- Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
- Terry Hyslop
- Department of Biostatistics and Bioinformatics, Duke University Medical Center
- Karl R. Clauser
- Broad Institute of Harvard and Massachusetts Institute of Technology
- D. R. Mani
- Broad Institute of Harvard and Massachusetts Institute of Technology
- Charles M. Perou
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- George Miles
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Bing Zhang
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Michael A. Gillette
- Broad Institute of Harvard and Massachusetts Institute of Technology
- Steven A. Carr
- Broad Institute of Harvard and Massachusetts Institute of Technology
- Matthew J. Ellis
- Lester and Sue Smith Breast Center and Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-14381-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Connecting genomics and proteomics allows the development of more efficient and specific treatments for cancer. Here, the authors develop proteogenomic methods to defining cancer signaling in-vivo starting from core needle biopsies and with application to a HER2 breast cancer focused clinical trial.
