Reversible epigenetic alterations regulate class I HLA loss in prostate cancer

Tamara S. Rodems; Erika Heninger; Charlotte N. Stahlfeld; Cole S. Gilsdorf; Kristin N. Carlson; Madison R. Kircher; Anupama Singh; Timothy E. G. Krueger; David J. Beebe; David F. Jarrard; Douglas G. McNeel; Michael C. Haffner; Joshua M. Lang

doi:10.1038/s42003-022-03843-6

Communications Biology (Sep 2022)

Reversible epigenetic alterations regulate class I HLA loss in prostate cancer

Tamara S. Rodems,
Erika Heninger,
Charlotte N. Stahlfeld,
Cole S. Gilsdorf,
Kristin N. Carlson,
Madison R. Kircher,
Anupama Singh,
Timothy E. G. Krueger,
David J. Beebe,
David F. Jarrard,
Douglas G. McNeel,
Michael C. Haffner,
Joshua M. Lang

Affiliations

Tamara S. Rodems: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison
Erika Heninger: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison
Charlotte N. Stahlfeld: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison
Cole S. Gilsdorf: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison
Kristin N. Carlson: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison
Madison R. Kircher: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison
Anupama Singh: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison
Timothy E. G. Krueger: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison
David J. Beebe: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison
David F. Jarrard: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison
Douglas G. McNeel: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison
Michael C. Haffner: Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center
Joshua M. Lang: University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison

DOI: https://doi.org/10.1038/s42003-022-03843-6
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

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Loss of HLA-I gene expression in prostate cancer is associated with repressive chromatin states, which can be reversed by pharmacological DNMT and HDAC inhibition leading to increased activation of co-cultured tumor-specific CD8+ T-cells.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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