PLoS ONE (Jan 2012)

Single endemic genotype of measles virus continuously circulating in China for at least 16 years.

  • Yan Zhang,
  • Songtao Xu,
  • Huiling Wang,
  • Zhen Zhu,
  • Yixin Ji,
  • Chunyu Liu,
  • Xiaojie Zhang,
  • Liwei Sun,
  • Jianhui Zhou,
  • Peishan Lu,
  • Ying Hu,
  • Daxing Feng,
  • Zhenying Zhang,
  • Changyin Wang,
  • Xueqiang Fang,
  • Huanying Zheng,
  • Leng Liu,
  • Xiaodong Sun,
  • Wei Tang,
  • Yan Wang,
  • Yan Liu,
  • Hui Gao,
  • Hong Tian,
  • Jiangtao Ma,
  • Suyi Gu,
  • Shuang Wang,
  • Yan Feng,
  • Fang Bo,
  • Jianfeng Liu,
  • Yuan Si,
  • Shujie Zhou,
  • Yuyan Ma,
  • Shengwei Wu,
  • Shunde Zhou,
  • Fangcai Li,
  • Zhengrong Ding,
  • Zhaohui Yang,
  • Paul A Rota,
  • David Featherstone,
  • Youngmee Jee,
  • William J Bellini,
  • Wenbo Xu

DOI
https://doi.org/10.1371/journal.pone.0034401
Journal volume & issue
Vol. 7, no. 4
p. e34401

Abstract

Read online

The incidence of measles in China from 1991 to 2008 was reviewed, and the nucleotide sequences from 1507 measles viruses (MeV) isolated during 1993 to 2008 were phylogenetically analyzed. The results showed that measles epidemics peaked approximately every 3 to 5 years with the range of measles cases detected between 56,850 and 140,048 per year. The Chinese MeV strains represented three genotypes; 1501 H1, 1 H2 and 5 A. Genotype H1 was the predominant genotype throughout China continuously circulating for at least 16 years. Genotype H1 sequences could be divided into two distinct clusters, H1a and H1b. A 4.2% average nucleotide divergence was found between the H1a and H1b clusters, and the nucleotide sequence and predicted amino acid homologies of H1a viruses were 92.3%-100% and 84.7%-100%, H1b were 97.1%-100% and 95.3%-100%, respectively. Viruses from both clusters were distributed throughout China with no apparent geographic restriction and multiple co-circulating lineages were present in many provinces. Cluster H1a and H1b viruses were co-circulating during 1993 to 2005, while no H1b viruses were detected after 2005 and the transmission of that cluster has presumably been interrupted. Analysis of the nucleotide and predicted amino acid changes in the N proteins of H1a and H1b viruses showed no evidence of selective pressure. This study investigated the genotype and cluster distribution of MeV in China over a 16-year period to establish a genetic baseline before MeV elimination in Western Pacific Region (WPR). Continuous and extensive MeV surveillance and the ability to quickly identify imported cases of measles will become more critical as measles elimination goals are achieved in China in the near future. This is the first report that a single endemic genotype of measles virus has been found to be continuously circulating in one country for at least 16 years.