Frontiers in Pharmacology (Jun 2021)

The Application of and Strategy for Gold Nanoparticles in Cancer Immunotherapy

  • Jia-shuai He,
  • Shi-jin Liu,
  • Yi-ran Zhang,
  • Xiao-dong Chu,
  • Zheng-bin Lin,
  • Zhan Zhao,
  • Sheng-hui Qiu,
  • Yan-guan Guo,
  • Hui Ding,
  • Yun-long Pan,
  • Jing-hua Pan

DOI
https://doi.org/10.3389/fphar.2021.687399
Journal volume & issue
Vol. 12

Abstract

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Immunotherapy of malignant tumor is a verified and crucial anti-tumor strategy to help patients with cancer for prolonging prognostic survival. It is a novel anticancer tactics that activates the immune system to discern and damage cancer cells, thereby prevent them from proliferating. However, immunotherapy still faces many challenges in view of clinical efficacy and safety issues. Various nanomaterials, especially gold nanoparticles (AuNPs), have been developed not only for anticancer treatment but also for delivering antitumor drugs or combining other treatment strategies. Recently, some studies have focused on AuNPs for enhancing cancer immunotherapy. In this review, we summarized how AuNPs applicated as immune agents, drug carriers or combinations with other immunotherapies for anticancer treatment. AuNPs can not only act as immune regulators but also deliver immune drugs for cancer. Therefore, AuNPs are candidates for enhancing the efficiency and safety of cancer immunotherapy.

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