Nature Communications (Aug 2021)
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior
- J. Blaze,
- A. Navickas,
- H. L. Phillips,
- S. Heissel,
- A. Plaza-Jennings,
- S. Miglani,
- H. Asgharian,
- M. Foo,
- C. D. Katanski,
- C. P. Watkins,
- Z. T. Pennington,
- B. Javidfar,
- S. Espeso-Gil,
- B. Rostandy,
- H. Alwaseem,
- C. G. Hahn,
- H. Molina,
- D. J. Cai,
- T. Pan,
- W. D. Yao,
- H. Goodarzi,
- F. Haghighi,
- S. Akbarian
Affiliations
- J. Blaze
- Department of Neuroscience, Icahn School of Medicine at Mt. Sinai
- A. Navickas
- Department of Biochemistry and Biophysics, University of California San Francisco
- H. L. Phillips
- Departments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, Upstate Medical University
- S. Heissel
- The Rockefeller University Proteomics Resource Center, The Rockefeller University
- A. Plaza-Jennings
- Department of Psychiatry, Icahn School of Medicine at Mt. Sinai
- S. Miglani
- Department of Biochemistry and Biophysics, University of California San Francisco
- H. Asgharian
- Department of Biochemistry and Biophysics, University of California San Francisco
- M. Foo
- Department of Biochemistry and Molecular Biology, University of Chicago
- C. D. Katanski
- Department of Biochemistry and Molecular Biology, University of Chicago
- C. P. Watkins
- Department of Biochemistry and Molecular Biology, University of Chicago
- Z. T. Pennington
- Department of Neuroscience, Icahn School of Medicine at Mt. Sinai
- B. Javidfar
- Friedman Brain Institute, Icahn School of Medicine at Mt. Sinai
- S. Espeso-Gil
- Friedman Brain Institute, Icahn School of Medicine at Mt. Sinai
- B. Rostandy
- The Rockefeller University Proteomics Resource Center, The Rockefeller University
- H. Alwaseem
- The Rockefeller University Proteomics Resource Center, The Rockefeller University
- C. G. Hahn
- Department of Neurosciences, Thomas Jefferson University
- H. Molina
- The Rockefeller University Proteomics Resource Center, The Rockefeller University
- D. J. Cai
- Department of Neuroscience, Icahn School of Medicine at Mt. Sinai
- T. Pan
- Department of Biochemistry and Molecular Biology, University of Chicago
- W. D. Yao
- Departments of Psychiatry and Behavioral Sciences, Neuroscience and Physiology, Upstate Medical University
- H. Goodarzi
- Department of Biochemistry and Biophysics, University of California San Francisco
- F. Haghighi
- Department of Neuroscience, Icahn School of Medicine at Mt. Sinai
- S. Akbarian
- Department of Neuroscience, Icahn School of Medicine at Mt. Sinai
- DOI
- https://doi.org/10.1038/s41467-021-24969-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
The link between tRNA modifications, protein translation, and behavior is unclear. Here, the authors show that neuronal Nsun2 deficiency results in codon-specific epitranscriptomic changes of Gly-tRNAs and proteomic changes affecting synaptic signaling and behavior in mice.
