Communications Biology (Apr 2022)
Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels
- Chloé Sarnowski,
- Mohsen Ghanbari,
- Joshua C. Bis,
- Mark Logue,
- Myriam Fornage,
- Aniket Mishra,
- Shahzad Ahmad,
- Alexa S. Beiser,
- Eric Boerwinkle,
- Vincent Bouteloup,
- Vincent Chouraki,
- L Adrienne Cupples,
- Vincent Damotte,
- Charles S. DeCarli,
- Anita L. DeStefano,
- Luc Djoussé,
- Alison E. Fohner,
- Carol E. Franz,
- Tiffany F. Kautz,
- Jean-Charles Lambert,
- Michael J. Lyons,
- Thomas H. Mosley,
- Kenneth J. Mukamal,
- Matthew P. Pase,
- Eliana C. Portilla Fernandez,
- Robert A. Rissman,
- Claudia L. Satizabal,
- Ramachandran S. Vasan,
- Amber Yaqub,
- Stephanie Debette,
- Carole Dufouil,
- Lenore J. Launer,
- William S. Kremen,
- William T. Longstreth,
- M Arfan Ikram,
- Sudha Seshadri
Affiliations
- Chloé Sarnowski
- Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston
- Mohsen Ghanbari
- Department of Epidemiology, Erasmus University Medical Center
- Joshua C. Bis
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Mark Logue
- National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System
- Myriam Fornage
- University of Texas Health Sciences Center at Houston
- Aniket Mishra
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219
- Shahzad Ahmad
- Department of Epidemiology, Erasmus University Medical Center
- Alexa S. Beiser
- Department of Biostatistics, Boston University School of Public Health
- Eric Boerwinkle
- University of Texas Health Sciences Center at Houston
- Vincent Bouteloup
- Centre Inserm U1219 Bordeaux Population Health, CIC1401-EC, Institut de Santé Publique, d’Epidémiologie et de Développement, Université de Bordeaux, CHU de Bordeaux, Pôle Santé Publique
- Vincent Chouraki
- Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases
- L Adrienne Cupples
- Department of Biostatistics, Boston University School of Public Health
- Vincent Damotte
- Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases
- Charles S. DeCarli
- Department of Neurology and Center for Neuroscience, University of California at Davis
- Anita L. DeStefano
- Department of Biostatistics, Boston University School of Public Health
- Luc Djoussé
- Department of Medicine, Division of Aging, Brigham and Women’s Hospital and Harvard Medical School
- Alison E. Fohner
- Institute of Public Health Genetics and Department of Epidemiology and Cardiovascular Health Research Unit, University of Washington
- Carol E. Franz
- Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego
- Tiffany F. Kautz
- Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, University of Texas Health Sciences Center
- Jean-Charles Lambert
- Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE- LabEx DISTALZ - Risk factors and molecular determinants of aging diseases
- Michael J. Lyons
- Department of Psychology and Brain Sciences, Boston University
- Thomas H. Mosley
- University of Mississippi Medical Center
- Kenneth J. Mukamal
- Beth Israel Deaconess Medical Center, Harvard Medical School
- Matthew P. Pase
- Turner Institute for Brain and Mental Health, Monash University
- Eliana C. Portilla Fernandez
- Department of Epidemiology, Erasmus University Medical Center
- Robert A. Rissman
- Department of Neurosciences, University of California, San Diego
- Claudia L. Satizabal
- Boston University and the NHLBI’s Framingham Heart Study
- Ramachandran S. Vasan
- Boston University and the NHLBI’s Framingham Heart Study
- Amber Yaqub
- Department of Epidemiology, Erasmus University Medical Center
- Stephanie Debette
- University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219
- Carole Dufouil
- Bordeaux University Hospital, Department of Neurology, Institute for Neurodegenerative Diseases
- Lenore J. Launer
- National Institute on Aging
- William S. Kremen
- Department of Psychiatry and Center for Behavior Genetics of Aging, University of California, San Diego
- William T. Longstreth
- Departments of Neurology and Epidemiology, University of Washington
- M Arfan Ikram
- Department of Epidemiology, Erasmus University Medical Center
- Sudha Seshadri
- Boston University and the NHLBI’s Framingham Heart Study
- DOI
- https://doi.org/10.1038/s42003-022-03287-y
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 11
Abstract
A meta-analysis of genome-wide association studies of circulating total-tau levels identifies loci specific to European or African American ancestries, providing further insight to the genetic etiology of neurological diseases.
