Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki (Mar 2021)

Characteristic of the chemical composition of Artemisia pontica L.

  • O. I. Panasenko,
  • V. I. Mozul,
  • O. M. Denysenko,
  • I. I. Aksonova,
  • T. V. Oberemko

DOI
https://doi.org/10.14739/2409-2932.2021.1.226743
Journal volume & issue
Vol. 14, no. 1
pp. 23 – 28

Abstract

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The aim of this work is to determine the qualitative and quantitative characteristics of biologically active compounds of Artemisia pontica L. Definition prospects of medicinal herbal raw materials in the treatment of diseases. Materials and methods. Research material (Artemisia pontica L. herb) was collected in August 2019 in the Zaporizhzhia region, Ukraine. The tincture was obtained by maceration. So, the tincture was being extracted with methyl alcohol at room temperature for 10 days. The tincture was extracted with methyl alcohol at room temperature for 10 days according to the method of preparing tinctures. The study of the chemical composition of tincture of Artemisia pontica L. was carried out using gas chromatograph Agilent 7890B GC System (Agilent, Santa Clara, CA, USA) with mass spectrometric detector Agilent 5977 BGC/MSD (Agilent, Santa Clara, CA, USA) and chromatographic column DB-5ms (30 m × 250 mkm × 0.25 mkm). Results. 26 compounds were identified by analysis. Compounds such as n-hexadecanoic acid (16.71 %), 9,12,15-(Z,Z,Z)-octadecatrienoic acid (13.29 %), 2-(4a,8-dimethyl-7-oxo-1,2,3,4,4a,7-hexahydronaphthalen-2-yl)-propionic acid (8.80 %), 8-nitro-(1H)quinolin-4-ol-2-one (6.45 %) and neophytadiene (4.66 %) prevail in tincture. A literature review showed that n-hexadecanoic acid stimulates anti-inflammatory processes in human immune cells through TLR4 receptors, it has antitumor and antidiabetic activity and it also has anti-inflammatory effects. Derivatives of 9,12,15-(Z,Z,Z)-octadecatrienoic acid are used in diabetes therapy. 2-(4a,8-Dimethyl-7-oxo-1,2,3,4,4a,7-hexahydronaphthalen-2-yl)-propionic acid is an immunosuppressant and probably improves tissue insulin sensitivity. In addition, it is necessary to underline the presence of neophytadiene that has an anti-inflammatory effect. The presence of β-phellandrene provides insecticidal and eucalyptol anti-inflammatory effects. Conclusions. Considering the individual actions of the individual components, Artemisia pontica L. herb can be recommended for further research on its anti-inflammatory, antidiabetic, and antitumor effects.

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