THE PROTEIN COMPOSITION OF SUBCELLULAR FRACTIONS SYNCYTIOTROPHOBLAST DURING PHYSIOLOGICAL PREGNANCY AND PLACENTAL INSUFFICIENCY

Abstract

Purpose: identify changes in the composition of cytoplasmic and membrane proteins of syncytiotrophoblast during placental insufficiency (PI).Materials and methods: we examined 64 women, the study group consisted of 34 patients with PI, a control group of 30 women with physiological pregnancy. Analysis of proteins was performed using a one-dimensional electrophoresis and gelchromatography.Results: carried out researches have allowed to establish in PI reliable differences in the quantity and the mobility of cytoplasmic and membrane proteins of syncytiotrophoblast with different molecular weights. For membrane proteins is also a change in the degree solubilize various detergents.Summary: detected modification of the composition and properties of proteins syncytiotrophoblast expands our understanding of the molecular mechanisms of development of PI.

Keywords

• placenta
• cytoplasmic and membrane proteins of syncytiotrophoblast
• placental insufficiency