Эндодонтия Today (Dec 2021)
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Abstract
Relevance. The effect of a tissue engineering construct based on synthetic octacalcium phosphate activated with pDNA-encoding VEGF on bone morphogenesis at the jaw defect sites of patients was studied. It is shown that the studied osteoplastic material stimulates osteogenesis pathways already at early stages, and xenogenic hydroxyapatite, triggers osteogenesis processes with considerable delay and does not have time to form a full-fledged bone structure by 6 months.Aim. Evaluate the dynamics of reparative osteogenesis based on the results of histomorphometric diagnostics in patients with defects in the jaw bones of various configurations and lengths with an implanted bone matrix based on synthetic octacalcium phosphate activated with pDNA-encoding VEGF.Materials and methods. Histomorphological examination of bone tissue biopsy of jaws was carried out in 20 patients of both genders, who needed additional volume of bone tissue to install dental implantation. Patients were divided into 2 groups by type of grafted material. 6 months after the surgery, bone biopsies were taken from the bone sites at the stage of implant placement. Histomorphological patterns and histotopograms were studied in bone biopcies.Results. In bone tissue biopsies of patients implanted with a tissue engineering construct based on synthetic octacalcium phosphate activated with pDNA-encoding VEGF, it was revealed that after 6 months there was prevaluation of mature bone tissue (42,71%), with the proportion of differentiated plate bone tissue being ~ 90%.Conclusions. Histomorphometric analysis showed that in patients implanted with a tissue engineering construct based on synthetic octacalcium phosphate pDNA-encoding VEGF, after 6 months, early rearrangement of bone tissue into a mechanically dense and highly mineralized structure was detected.
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