A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions

Sebastian G. Wicha; Chunli Chen; Oskar Clewe; Ulrika S. H. Simonsson

doi:10.1038/s41467-017-01929-y

Nature Communications (Dec 2017)

A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions

Sebastian G. Wicha,
Chunli Chen,
Oskar Clewe,
Ulrika S. H. Simonsson

Affiliations

Sebastian G. Wicha: Department of Pharmaceutical Biosciences, Uppsala University
Chunli Chen: Department of Pharmaceutical Biosciences, Uppsala University
Oskar Clewe: Department of Pharmaceutical Biosciences, Uppsala University
Ulrika S. H. Simonsson: Department of Pharmaceutical Biosciences, Uppsala University

DOI: https://doi.org/10.1038/s41467-017-01929-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Assessment of pharmacodynamic interactions is at the heart of combination therapy development. Here the authors introduce a general drug interaction scoring model that enables quantification of synergistic and antagonistic interactions and determination of the directionality of the interactions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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