Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production

Chi-I Chang; Chien-Chih Chen; Che-Yi Chao; Sheng-Yang Wang; Hsun-Shuo Chang; Ping-Jyun Sung; Guan-Jhong Huang; Yen-Cheng Li; Yueh-Hsiung Kuo

doi:10.3390/molecules21040490

Molecules (Apr 2016)

Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production

Chi-I Chang,
Chien-Chih Chen,
Che-Yi Chao,
Sheng-Yang Wang,
Hsun-Shuo Chang,
Ping-Jyun Sung,
Guan-Jhong Huang,
Yen-Cheng Li,
Yueh-Hsiung Kuo

Affiliations

Chi-I Chang: Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
Chien-Chih Chen: Department of Biotechnology, Hungkuang University, Taichung 443, Taiwan
Che-Yi Chao: Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan
Sheng-Yang Wang: Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan
Hsun-Shuo Chang: School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Ping-Jyun Sung: Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Guan-Jhong Huang: School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
Yen-Cheng Li: Department of Chemistry, National Taiwan University, Taipei 106, Taiwan
Yueh-Hsiung Kuo: School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan

DOI: https://doi.org/10.3390/molecules21040490
Journal volume & issue: Vol. 21, no. 4
p. 490

Abstract

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Three new sesquiterpenoids, 2α-hydroxy-3,3,6α,9β-tetramethyltricyclo[4,3,21,4]undecane (1), 11-acetoxyeudesman-4β-ol (4), and 2α,3β-dihydroxy-4β-methyl-6,8,10-cadinatriene (6), four known sesquiterpenoids (2, 3, 5, and 7), together with eight known diterpenoids (8–15), were isolated from the wood of Cunninghamia konishii. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. Four sesquiterpenoids (1, 4, 5, and 6) and all the diterpenoids (8–15) were evaluated for inhibition of nitric oxide production in lipopolysaccharides (LPS)-activated RAW 264.7 macrophages and the results showed that compounds 10 and 15 exhibited moderate inhibitory activities against nitric oxide production.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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