Nature Communications (Aug 2021)
MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer
- C. Kalogirou,
- J. Linxweiler,
- P. Schmucker,
- M. T. Snaebjornsson,
- W. Schmitz,
- S. Wach,
- M. Krebs,
- E. Hartmann,
- M. Puhr,
- A. Müller,
- M. Spahn,
- A. K. Seitz,
- T. Frank,
- H. Marouf,
- G. Büchel,
- M. Eckstein,
- H. Kübler,
- M. Eilers,
- M. Saar,
- K. Junker,
- F. Röhrig,
- B. Kneitz,
- M. T. Rosenfeldt,
- A. Schulze
Affiliations
- C. Kalogirou
- Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter
- J. Linxweiler
- Department of Urology, Saarland University
- P. Schmucker
- Department of Urology and Paediatric Urology, University Hospital Würzburg
- M. T. Snaebjornsson
- German Cancer Research Center, Division of Tumor Metabolism and Microenvironment
- W. Schmitz
- Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter
- S. Wach
- Department of Urology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg
- M. Krebs
- Department of Urology and Paediatric Urology, University Hospital Würzburg
- E. Hartmann
- Institute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) Mainfranken
- M. Puhr
- Department of Urology, Medical University of Innsbruck
- A. Müller
- Clinic for Diagnostic and Interventional Radiology, Saarland University
- M. Spahn
- Center for Urology, Hirslanden Private Hospital Group
- A. K. Seitz
- Department of Urology and Paediatric Urology, University Hospital Würzburg
- T. Frank
- Department of Urology and Paediatric Urology, University Hospital Würzburg
- H. Marouf
- Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter
- G. Büchel
- Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter
- M. Eckstein
- Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg
- H. Kübler
- Department of Urology and Paediatric Urology, University Hospital Würzburg
- M. Eilers
- Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter
- M. Saar
- Department of Urology, Saarland University
- K. Junker
- Department of Urology, Saarland University
- F. Röhrig
- Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter
- B. Kneitz
- Department of Urology and Paediatric Urology, University Hospital Würzburg
- M. T. Rosenfeldt
- Institute of Pathology, Julius Maximilians University and Comprehensive Cancer Center (CCC) Mainfranken
- A. Schulze
- Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter
- DOI
- https://doi.org/10.1038/s41467-021-25325-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the rate-limiting enzyme of cholesterol synthesis, squalene epoxidase.
