PRUKALOPRIDE IN THE TREATMENT OF CHRONIC CONSTIPATION

Abstract

The article provides factors that are involved in development of constipation. The main concern is the impairment of the motor function of the intestine, which is characterized by the ineffective movement of the contents of the colon. The pharmacological effect on 5NT4 -serotonin receptors of patients is the most physiological way to restore the motor functions of the intestine, which preserves the daily rhythms of the defecation, initiate its high-amplitude propulsion reductions without significant side effects characteristic of some enterokinetic agents and laxatives. The use of prukalopride is a method of such action. It is effective in the case of chronic constipation and provides new therapeutic alternatives to patients whose symptoms have not been completely eliminated by laxatives. A new Russian prukalopride Vegaprat was launched.

Keywords

• constipation
• 5nt₄-serotonin receptors
• laxatives
• prukalopride