Antibacterial evaluation of 2-(6-Chloro-2-p-tolylquinazolin-4-ylthio) acetonitrile against pathogenic bacterial isolates with special reference to biofilm formation inhibition and anti-adherence properties

Abstract

Background: Evaluating the effectiveness of a specific quinazoline molecule with antibacterial activity on microorganisms as a potential antibiotic substitution. Methods: A variety of microorganisms were tested with the designated quinazoline molecule. Differences within two groups were analyzed using the two-tailed Student’s t-test,. Results: Susceptibility tests revealed that the chemical has stronger antibacterial action against S. saprophyticus than other isolates, with just a slight effect on E. coli and M. smegmatis. The bacterial cells were subjected to varying concentrations of a certain molecule, and the results showed that the inhibition of bacterial adhesion was not consistent. This suggests that the effect of the molecule on bacterial adhesion is dependent on its concentration. After 24 h of treatment with varying chemical doses, all of the periodontal bacterial strains examined showed considerable inhibition of biofilm formation. Conclusions: According to the findings, the chemical molecule quinazoline could be utilized as an alternative therapeutic approach for microorganism-caused infections.

Keywords

• Quinazoline
• Antibacterial
• Microorganisms
• Biofilm
• EGFR