Frontiers in Pharmacology (Jul 2024)

Clinical risk factors for moderate and severe antituberculosis drug-induced liver injury

  • Quanxian Liu,
  • Lu Huang,
  • Hong Yan,
  • Zhaojing Zong,
  • Zhenyong Chen,
  • Xiaoyan Wu,
  • Ling Chen,
  • Yuanbo Lan

DOI
https://doi.org/10.3389/fphar.2024.1406454
Journal volume & issue
Vol. 15

Abstract

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ObjectiveTo analyze the clinical and laboratory characteristics and to identify predictors of moderate to severe anti-tuberculosis drug-induced liver injury (ATB-DILI) in patients with tuberculosis.MethodsThis prospective study enrolled Tuberculosis (TB) patients treated with first-line anti-tuberculosis drugs at the Affiliated Hospital of Zunyi Medical University between May 2022 and June 2023. The occurrence of ATB-DILI was monitored, and demographic and clinical data were gathered. We analyzed risk factors for the development of moderate to severe ATB-DILI.ResultsATB-DILI was detected in 120 (10.7%) of the patients, with moderate to severe ATB-DILI occurring in 23 (2.0%) of the 1,124 patients treated with anti-tuberculosis treatment. Multivariate cox regression analysis identified malnutrition (HR = 4.564, 95% CI: 1.029–20.251, p = 0.046) and hemoglobin levels <120 g/L (HR = 2.825, 95% CI: 1.268–11.540, p = 0.017) as independent risk factors for moderate to severe ATB-DILI.ConclusionThe incidence of moderate to severe ATB-DILI was found to be 2.0%. Malnutrition and hemoglobin levels below 120 g/L emerged as significant independent risk factors for the occurrence of moderate to severe ATB-DILI in this patient population.

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