Loss of PRC2 subunits primes lineage choice during exit of pluripotency

Chet H. Loh; Siebe van Genesen; Matteo Perino; Magnus R. Bark; Gert Jan C. Veenstra

doi:10.1038/s41467-021-27314-4

Nature Communications (Nov 2021)

Loss of PRC2 subunits primes lineage choice during exit of pluripotency

Chet H. Loh,
Siebe van Genesen,
Matteo Perino,
Magnus R. Bark,
Gert Jan C. Veenstra

Affiliations

Chet H. Loh: Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University
Siebe van Genesen: Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University
Matteo Perino: Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University
Magnus R. Bark: Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University
Gert Jan C. Veenstra: Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University

DOI: https://doi.org/10.1038/s41467-021-27314-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Polycomb Repressive Complex 2, an important regulator of embryonic development, exists in two configurations, PRC2.1 and PRC2.2. Here the authors dissect the functional contributions of these two PRC2 subunits and observed complex-specific alterations in the cell state of pluripotent and early differentiating cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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