Frontiers in Surgery (Nov 2021)
Prediction of Graft Survival Post-liver Transplantation by L-GrAFT Risk Score Model, EASE Score, MEAF Scoring, and EAD
- Shirui Chen,
- Shirui Chen,
- Shirui Chen,
- Tielong Wang,
- Tielong Wang,
- Tielong Wang,
- Tao Luo,
- Tao Luo,
- Tao Luo,
- Shujiao He,
- Shujiao He,
- Shujiao He,
- Changjun Huang,
- Changjun Huang,
- Changjun Huang,
- Zehua Jia,
- Zehua Jia,
- Zehua Jia,
- Liqiang Zhan,
- Liqiang Zhan,
- Liqiang Zhan,
- Dongping Wang,
- Dongping Wang,
- Dongping Wang,
- Xiaofeng Zhu,
- Xiaofeng Zhu,
- Xiaofeng Zhu,
- Zhiyong Guo,
- Zhiyong Guo,
- Zhiyong Guo,
- Xiaoshun He,
- Xiaoshun He,
- Xiaoshun He
Affiliations
- Shirui Chen
- Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Shirui Chen
- Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China
- Shirui Chen
- Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China
- Tielong Wang
- Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Tielong Wang
- Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China
- Tielong Wang
- Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China
- Tao Luo
- Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Tao Luo
- Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China
- Tao Luo
- Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China
- Shujiao He
- Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Shujiao He
- Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China
- Shujiao He
- Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China
- Changjun Huang
- Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Changjun Huang
- Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China
- Changjun Huang
- Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China
- Zehua Jia
- Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Zehua Jia
- Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China
- Zehua Jia
- Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China
- Liqiang Zhan
- Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Liqiang Zhan
- Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China
- Liqiang Zhan
- Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China
- Dongping Wang
- Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Dongping Wang
- Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China
- Dongping Wang
- Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China
- Xiaofeng Zhu
- Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Xiaofeng Zhu
- Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China
- Xiaofeng Zhu
- Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China
- Zhiyong Guo
- Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Zhiyong Guo
- Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China
- Zhiyong Guo
- Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China
- Xiaoshun He
- Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Xiaoshun He
- Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, China
- Xiaoshun He
- Guangdong Provincial International Cooperation Base of Science and Technology, Guangzhou, China
- DOI
- https://doi.org/10.3389/fsurg.2021.753056
- Journal volume & issue
-
Vol. 8
Abstract
Background: Early allograft dysfunction (EAD) is correlated with poor patient or graft survival in liver transplantation. However, the power of distinct definitions of EAD in prediction of graft survival is unclear.Methods: This retrospective, single-center study reviewed data of 677 recipients undergoing orthotopic liver transplant between July 2015 and June 2020. The following EAD definitions were compared: liver graft assessment following transplantation (L-GrAFT) risk score model, early allograft failure simplified estimation score (EASE), model for early allograft function (MEAF) scoring, and Olthoff criteria. Risk factors for L-GrAFT7 high risk group were evaluated with univariate and multivariable logistic regression analysis.Results: L-GrAFT7 had a satisfied C-statistic of 0.87 in predicting a 3-month graft survival which significantly outperformed MEAF (C-statistic = 0.78, P = 0.01) and EAD (C-statistic = 0.75, P < 0.001), respectively. L-GrAFT10, EASE was similar to L-GrAFT7, and they had no statistical significance in predicting survival. Laboratory model for end-stage liver disease score and cold ischemia time are risk factors of L-GrAFT7 high-risk group.Conclusion: L-GrAFT7 risk score is capable for better predicting the 3-month graft survival than the MEAF and EAD in a Chinese cohort, which might standardize assessment of early graft function and serve as a surrogate endpoint in clinical trial.
Keywords
- orthotopic liver transplantation
- risk prediction model
- machine perfusion
- risk factor
- graft survival
- patient survivability
