ALA-PDT combined with CO2 laser in the treatment of malignant hidroacanthoma simplex: A case report

Yulu Chen; Mingshun Wu; Lianjun Chen; Zhenlin Li; Zhongxia Zhou; Wei Li; Guolong Zhang

Photodiagnosis and Photodynamic Therapy (Oct 2024)

ALA-PDT combined with CO2 laser in the treatment of malignant hidroacanthoma simplex: A case report

Yulu Chen,
Mingshun Wu,
Lianjun Chen,
Zhenlin Li,
Zhongxia Zhou,
Wei Li,
Guolong Zhang

Affiliations

Yulu Chen: Skin Cancer Center & Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China; Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
Mingshun Wu: Skin Cancer Center & Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China; Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
Lianjun Chen: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China
Zhenlin Li: Skin Cancer Center & Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China; Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
Zhongxia Zhou: Skin Cancer Center & Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China; Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China
Wei Li: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Corresponding authors.
Guolong Zhang: Skin Cancer Center & Department of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China; Institute of Photomedicine, School of Medicine, Tongji University, Shanghai, China; Corresponding authors.

Journal volume & issue: Vol. 49
p. 104299

Abstract

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Hidroacanthoma simplex (HS) is a rare skin appendage tumor that typically appears on the trunk and lower limbs in the elderly. Although HS is a predominantly benign condition, the presence of cellular atypia and dermal infiltration on histological examination indicates malignant HS (MHS). 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) uses a photosensitizer and corresponding light source to cause irreversible damage or death of target cells through a photochemical reaction. Here, we reported the successful treatment of a MHS patient with ALA-PDT using plum-blossom needle pretreatment combined with CO2 laser. After five courses of ALA-PDT, the lesions were completely resolved, and the autonomic activity and smooth surface of the left ring finger were restored. This suggests that ALA-PDT is an effective, minimally invasive and safe treatment modality for MHS.

Published in Photodiagnosis and Photodynamic Therapy

ISSN: 1572-1000 (Print); 1873-1597 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General)
Website: https://www.sciencedirect.com/journal/photodiagnosis-and-photodynamic-therapy

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