Ionic signalling and mitochondrial dynamics

Abstract

In age-related diseases, rise in intracellular reactive oxygen species (ROS) causes fragmentation of mitochondrial network. Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysosomal Zn2+ release that, in turn, triggers mitochondrial fragmentation. The findings provide new mechanistic insights that may have therapeutic implications.

Keywords

• calcium
• cell proliferation
• cell migration
• lysosomal membrane permeabilisation
• mitochondrial dynamics
• oxidative stress
• reactive oxygen species
• trpm2
• zinc