A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space

Jose R. Garcia, MS; Peter F. Campbell, MD; Gautam Kumar, MBBS; Jonathan J. Langberg, MD; Liliana Cesar, DVM; Lanfang Wang, MS; Andrés J. García, PhD; Rebecca D. Levit, MD

doi:10.1016/j.jacbts.2017.06.003

JACC: Basic to Translational Science (Oct 2017)

A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space

Jose R. Garcia, MS,
Peter F. Campbell, MD,
Gautam Kumar, MBBS,
Jonathan J. Langberg, MD,
Liliana Cesar, DVM,
Lanfang Wang, MS,
Andrés J. García, PhD,
Rebecca D. Levit, MD

Affiliations

Jose R. Garcia, MS: Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia
Peter F. Campbell, MD: Innovatië LifeSciences, Santa Clara, California
Gautam Kumar, MBBS: Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
Jonathan J. Langberg, MD: Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
Liliana Cesar, DVM: T3 Labs-Translational, Testing and Training Laboratories, Inc., Atlanta, Georgia
Lanfang Wang, MS: Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
Andrés J. García, PhD: Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia
Rebecca D. Levit, MD: Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia

DOI: https://doi.org/10.1016/j.jacbts.2017.06.003
Journal volume & issue: Vol. 2, no. 5
pp. 601 – 609

Abstract

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Biomaterials are a new treatment strategy for cardiovascular diseases but are difficult to deliver to the heart in a safe, precise, and translatable way. We developed a method to deliver hydrogels to the epicardium through the pericardial space. Our device creates a temporary compartment for hydrogel delivery and gelation using anatomic structures. The method minimizes risk to patients from embolization, thrombotic occlusion, and arrhythmia. In pigs there were no clinically relevant acute or subacute adverse effects from pericardial hydrogel delivery, making this a translatable strategy to deliver biomaterials to the heart.

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

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