Nature Communications (Oct 2021)
Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host
- Verónica Lloréns-Rico,
- Ann C. Gregory,
- Johan Van Weyenbergh,
- Sander Jansen,
- Tina Van Buyten,
- Junbin Qian,
- Marcos Braz,
- Soraya Maria Menezes,
- Pierre Van Mol,
- Lore Vanderbeke,
- Christophe Dooms,
- Jan Gunst,
- Greet Hermans,
- Philippe Meersseman,
- CONTAGIOUS collaborators,
- Els Wauters,
- Johan Neyts,
- Diether Lambrechts,
- Joost Wauters,
- Jeroen Raes
Affiliations
- Verónica Lloréns-Rico
- Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven
- Ann C. Gregory
- Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven
- Johan Van Weyenbergh
- Laboratory for Clinical and Evolutionary Virology, Department of Microbiology and Immunology, Rega Institute, KU Leuven
- Sander Jansen
- Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- Tina Van Buyten
- Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- Junbin Qian
- Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, Zhejiang University School of Medicine
- Marcos Braz
- Laboratory for Clinical and Evolutionary Virology, Department of Microbiology and Immunology, Rega Institute, KU Leuven
- Soraya Maria Menezes
- Laboratory for Clinical and Evolutionary Virology, Department of Microbiology and Immunology, Rega Institute, KU Leuven
- Pierre Van Mol
- Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven
- Lore Vanderbeke
- Laboratory of Clinical Bacteriology and Mycology, Department of Microbiology, Immunology and Transplantation, KU Leuven
- Christophe Dooms
- Department of Pneumology, University Hospitals Leuven
- Jan Gunst
- Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven
- Greet Hermans
- Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven
- Philippe Meersseman
- Laboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven
- CONTAGIOUS collaborators
- Els Wauters
- Department of Pneumology, University Hospitals Leuven
- Johan Neyts
- Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- Diether Lambrechts
- Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven
- Joost Wauters
- Laboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven
- Jeroen Raes
- Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven
- DOI
- https://doi.org/10.1038/s41467-021-26500-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Here, the authors profile the respiratory microbiome of COVID-19 patients and link clinical practices, such as mechanical ventilation, with vast changes in the microbiota. In the lungs, oral bacteria are found physically associated with proinflammatory immune cells, thus possibly contributing to exacerbated immune responses in severe disease
