Nature Communications (Jun 2021)

Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine

  • Michael Prattes,
  • Irina Grishkovskaya,
  • Victor-Valentin Hodirnau,
  • Ingrid Rössler,
  • Isabella Klein,
  • Christina Hetzmannseder,
  • Gertrude Zisser,
  • Christian C. Gruber,
  • Karl Gruber,
  • David Haselbach,
  • Helmut Bergler

DOI
https://doi.org/10.1038/s41467-021-23854-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large subunit. Here the authors report the structure of Drg1 in complex with its specific inhibitor diazaborine and provide insight into the mechanism of inhibition and specificity of this class of inhibitors.