mBio (Feb 2021)

Experimental Human Challenge Defines Distinct Pneumococcal Kinetic Profiles and Mucosal Responses between Colonized and Non-Colonized Adults

  • Elissavet Nikolaou,
  • Simon P. Jochems,
  • Elena Mitsi,
  • Sherin Pojar,
  • Annie Blizard,
  • Jesus Reiné,
  • Carla Solórzano,
  • Edessa Negera,
  • Beatriz Carniel,
  • Alessandra Soares-Schanoski,
  • Victoria Connor,
  • Hugh Adler,
  • Seher R. Zaidi,
  • Caz Hales,
  • Helen Hill,
  • Angie Hyder-Wright,
  • Stephen B. Gordon,
  • Jamie Rylance,
  • Daniela M. Ferreira

DOI
https://doi.org/10.1128/mBio.02020-20
Journal volume & issue
Vol. 12, no. 1

Abstract

Read online

Occurrence of lower respiratory tract infections requires prior colonization of the upper respiratory tract with a pathogen. Most bacterial infection and colonization studies have been performed in murine and in vitro